Show simple item record

dc.contributor.authorHoang, Diem Huong
dc.contributor.authorNguyen, Dac Tu
dc.contributor.authorNguyen, Hoang Phuong
dc.contributor.authorNguyen, Xuan Hung
dc.contributor.authorDo, Thi Xuan Phuong
dc.contributor.authorDang, Van Duc
dc.contributor.authorDam, Thi Minh Phuong
dc.contributor.authorNguyen, Thanh Liem
dc.contributor.authorTran, Thi Trang Uyen
dc.date.accessioned2025-03-24T05:50:46Z
dc.date.available2025-03-24T05:50:46Z
dc.date.issued2020-06-24
dc.identifier.urihttps://vinspace.edu.vn/handle/VIN/621
dc.description.abstractExosomes are nano-scale and closed membrane vesicles which are promising for therapeutic applications due to exosome-enclosed therapeutic molecules such as DNA, small RNAs, proteins, and lipids. Recently, it has been demonstrated that mesenchymal stem cell (MSC)-derived exosomes have the capacity to regulate many biological events associated with the wound healing process, such as cell proliferation, cell migration, and blood vessel formation. This study investigated the regenerative potentials for cutaneous tissue, in regard to growth factors associated with wound healing and skin cell proliferation and migration, by exosomes released from primary MSCs originated from bone marrow (BM), adipose tissue (AD), and umbilical cord (UC) under serum- and xeno-free conditions. We found crucial wound healing-mediated growth factors, such as vascular endothelial growth factor A (VEGF-A), fibroblast growth factor 2 (FGF-2), hepatocyte growth factor (HGF), and platelet-derived growth factor BB (PDGF-BB) in exosomes derived from all three MSC sources. However, expression levels of these growth factors in exosomes were influenced by MSC origins, especially transforming growth factor beta (TGF-β) which was only detected in UCMSC-derived exosomes. All exosomes released by the three MSC sources induced keratinocyte and fibroblast proliferation and migration; and the induction of cell migration is dependent on the manner in which the higher dose of exosomes was used (20 µg), with a faster migration rate observed. Additionally, the influences of exosomes on cell proliferation and migration were associated with exosome origins and also target cells of exosomes, with the greatest induction of primary dermal fibroblasts belonging to BMMSC-derived exosomes and keratinocytes to UCMSC-derived exosomes. Data from this study indicated that BMMSCs and UCMSCs under clinical conditions secreted exosomes are promising to develop into therapeutic products for wound healing treatment.en_US
dc.language.isoen_USen_US
dc.subjectexosomesen_US
dc.subjectmesenchymal stem cellsen_US
dc.subjectbmmsc-derived exosomesen_US
dc.subjectadmsc-derived exosomesen_US
dc.subjectucmsc-derived exosomesen_US
dc.subjectgrowth factorsen_US
dc.subjectwound healingen_US
dc.titleDifferential wound healing capacity of mesenchymal stem cell-derived exosomes originated from bone marrow, adipose tissue, and umbilical cord under serum- and xeno-free conditionen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record


Vin University Library
Da Ton, Gia Lam
Vinhomes Oceanpark, Ha Noi, Viet Nam
Phone: +84-2471-089-779 | 1800-8189
Contact: library@vinuni.edu.vn