Nguyen Thanh Liem, MD, PhD
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Prof. Nguyen Thanh Liem is a pioneer and innovator in pediatrics endoscopic surgery and stem cell transplantation . He graduated from Hanoi Medical University in 1976 and completed medical residency program in Surgery at Viet Duc Hospital in 1979. He defended his PhD. thesis in 1991 and was appointed as a Medical Professor in Surgery in 2009. He is internationally recognized inventor by his seven advanced operative techniques in the Pediatrics Surgery. Regarding the stem cell studies, Prof. Liem is a pioneer of using stem cell therapy for unmet diseases in children such as cerebral palsy due to oxygen deprivation, due to neonatal icterus, due to intracranial hemorrhage, neurological sequelae after nearly death drwoning, Autism, bronchopulmonary dysplasia, and liver cirrhosis due to biliary atresia. Throughout his career, he has been in charge of a number of important positions such as Director of Vietnam National Children Hospital from 2002 to 2012; Director of Vinmec International Hospital from 2013-2016; Vice president of Asian Association of Pediatric Surgery; President of Vietnam Association of Pediatric Surgery. Currently, Prof. Liem is the director of Vinmec Research Institute of Stem Cell and Gene Technology.
Recent Submissions
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“Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction: Literature reviews and study design of a clinical trial”
(2022-09-28)Hormone imbalance and female sexual dysfunction immensely affect perimenopausal female health and quality of life. Hormone therapy can improve female hormone deficiency, but long-term use increases the risk of cardiovascular ... -
Human umbilical cord mesenchymal stem cells for severe neurological sequelae due to anti-N-methyl-d-aspartate receptor encephalitis: First case report
(2022-06-15)Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is caused by altered patient immune reactions. This study reports the first patient with severe neurologic sequelae after NMDA receptor encephalitis treated with ... -
Cytokine-primed umbilical cord mesenchymal stem cells enhanced therapeutic effects of extracellular vesicles on osteoarthritic chondrocytes
(2022-10-27)In recent years, extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) have emerged as a potential cell-free therapy against osteoarthritis (OA). Thus, we investigated the therapeutic effects of EVs released ... -
Optimization of human umbilical cord blood-derived mesenchymal stem cell isolation and culture methods in serum- and xeno-free conditions
(2022-12)Background: Although umbilical cord blood (UCB) is identified as a source of mesenchymal stem cells (MSCs) with various advantages, the success in cell isolation is volatile. Therefore, it is necessary to optimize methods ... -
Autologous bone marrow mononuclear cell infusion for liver cirrhosis after the Kasai operation in children with biliary atresia
(2022-12)Aim: To evaluate the safety and early outcomes of autologous bone marrow mononuclear cell (BMMNC) infusion for liver cirrhosis due to biliary atresia (BA) after Kasai operation. Methods: An open-label clinical trial was ... -
The correlation between peripheral blood index and immune cell expansion in Vietnamese elderly lung cancer patients
(2023-02-21)(1) Background: The dysfunction and reduced proliferation of peripheral CD8+ T cells and natural killer (NK) cells have been observed in both aging and cancer patients, thereby challenging the adoption of immune cell therapy ... -
The density of bone marrow mononuclear cells and CD34+ cells in patients with three neurologic conditions
(2023)Background This study aimed to identify the density of mononuclear cells (MNCs) and CD34+ cells in the bone mar‑row of patients with three neurologic conditions. Methods The study included 88 patients with three neurologic ... -
Outcomes of autologous bone marrow mononuclear cell administration in the treatment of neurologic sequelae in children with spina bifida
(2023)Background To evaluate the safety and efcacy of autologous bone marrow mononuclear cell (BMMNC) infusion in the management of neurological sequelae in children with spina bifda (SB). Methods BMMNCs were harvested from ... -
Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti-N-Methyl-d-Aspartate Receptor Encephalitis: First Case Report
(2022-06-15)Background: Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis results from altered immune responses and can lead to severe neurological sequelae. This study presents the first case of a patient with significant ... -
The Correlation between Peripheral Blood Index and Immune Cell Expansion in Vietnamese Elderly Lung Cancer Patients
(2023-02-21)(1) Background: The dysfunction and reduced proliferation of peripheral CD8+ T cells and natural killer (NK) cells have been observed in both aging and cancer patients, thereby challenging the adoption of immune cell therapy ... -
The density of bone marrow mononuclear cells and CD34+ cells in patients with three neurologic conditions
(2023)Background: This study aimed to identify the density of mononuclear cells (MNCs) and CD34+ cells in the bone marrow of patients with three neurologic conditions. Methods: The study included 88 patients with three ... -
Human umbilical cord mesenchymal stem cells for severe neurological sequelae due to anti-N-methyl-d-aspartate receptor encephalitis: First case report
(2022-06-15)Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis results from altered immune responses and can lead to severe neurological sequelae. This study presents the first case of a patient with significant neurological ... -
Bone Marrow‐Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns
(2023-06-14)Bone marrow-derived mononuclear cells (BMMNCs) have been used for decades in preclinical and clinical studies to treat various neurological diseases. However, there is still a knowledge gap in the understanding of the ... -
Autologous bone marrow mononuclear cell infusion for liver cirrhosis after the Kasai operation in children with biliary atresia
(2022-03-14)Aim: To evaluate the safety and early outcomes of autologous bone marrow mononuclear cell (BMMNC) infusion for liver cirrhosis due to biliary atresia (BA) after Kasai operation. Methods: An open-label clinical trial was ... -
Advanced cell-based products generated via automated and manual manufacturing platforms under the quality by design principle: Are they equivalent or different?
(2023-04-27)Mesenchymal stem/stromal cells (MSCs) are multipotent stem cells that can be isolated from bone marrow, adipose tissue, the umbilical cord, dental pulp, etc. These cells have unique properties that give them excellent ... -
Influences of Xeno-Free Media on Mesenchymal Stem Cell Expansion for Clinical Application
(2020-09-27)Mesenchymal stem/stromal cells (MSCs) are multipotent somatic stem/progenitor cells that can be isolated from various tissues and have attracted increasing attention from the scientific community. This is due to MSCs showing ... -
Induction of Antitumor Immunity by Exosomes Isolated from Cryopreserved Cord Blood Monocyte-Derived Dendritic Cells
(2020-03-06)(1) Background: Dendritic cell (DC) vaccination has shown outstanding achievements in cancer treatment, although it still has some adverse side effects. Vaccination with DC-derived exosomes has been thought to overcome the ... -
Evaluating the Safety and Quality of Life of Colorectal Cancer Patients Treated by Autologous Immune Enhancement Therapy (AIET) in Vinmec International Hospitals
(2022-09)(1) Colorectal cancer (CRC) is an increasingly prevalent disease with a high mortality rate in recent years. Immune cell-based therapies have received massive attention among scientists, as they have been proven effective ... -
Cytokine-primed umbilical cord mesenchymal stem cells enhanced therapeutic effects of extracellular vesicles on osteoarthritic chondrocytes
(2022-10)In recent years, extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) have emerged as a potential cell-free therapy against osteoarthritis (OA). Thus, we investigated the therapeutic effects of EVs released ... -
Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction: Literature reviews and study design of a clinical trial
(2022-09)Hormone imbalance and female sexual dysfunction immensely affect perimenopausal female health and quality of life. Hormone therapy can improve female hormone deficiency, but long-term use increases the risk of cardiovascular ...
