Glucose sensors based on chitosan capped ZnS doped Mn nanomaterials

Abstract

A typical glucose sensor is a glucose oxidase (GOx) enzyme-based sensor due to its high sensitivity and selectivity. However, activating and stabilizing the enzyme presents challenges. To enhance the stability of GOx-based sensors, chitosan is added to ZnS-doped Mn nanoparticles. Chitosan stabilizes the ZnS-doped Mn particles and can induce charge processes such as creation, transfer, and separation at the polymer interface and the nanoparticles' interface. Thus, it is a strong candidate for electrochemical glucose sensing applications.

This letter reports on an impedance biosensor based on ZnS-doped Mn-capped chitosan nanomaterials and microinterdigitated electrodes. The glucose sensors demonstrated high sensitivity, accuracy, and stability in the concentration range of 2 to 10 mM. Additionally, the application of Canny edge detection was employed to enhance the limit of detection, as demonstrated using experimental data.