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Cytokine-primed umbilical cord mesenchymal stem cells enhanced therapeutic effects of extracellular vesicles on osteoarthritic chondrocytes
(2022-10)
In recent years, extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) have emerged as a potential cell-free therapy against osteoarthritis (OA). Thus, we investigated the therapeutic effects of EVs released ...
Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction: Literature reviews and study design of a clinical trial
(2022-09)
Hormone imbalance and female sexual dysfunction immensely affect perimenopausal female health and quality of life. Hormone therapy can improve female hormone deficiency, but long-term use increases the risk of cardiovascular ...
Induction of Antitumor Immunity by Exosomes Isolated from Cryopreserved Cord Blood Monocyte-Derived Dendritic Cells
(2020-03-06)
(1) Background: Dendritic cell (DC) vaccination has shown outstanding achievements in cancer treatment, although it still has some adverse side effects. Vaccination with DC-derived exosomes has been thought to overcome the ...
Influences of Xeno-Free Media on Mesenchymal Stem Cell Expansion for Clinical Application
(2020-09-27)
Mesenchymal stem/stromal cells (MSCs) are multipotent somatic stem/progenitor cells that can be isolated from various tissues and have attracted increasing attention from the scientific community. This is due to MSCs showing ...
Human umbilical cord mesenchymal stem cells for severe neurological sequelae due to anti-N-methyl-d-aspartate receptor encephalitis: First case report
(2022-06-15)
Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis results from altered immune responses and can lead to severe neurological sequelae. This study presents the first case of a patient with significant neurological ...
Outcomes of bone marrow-derived mononuclear cell transplantation for patients in persistent vegetative state after drowning: Report of five cases
(2020-09)
Aim: Anoxic brain injury (ABI) due to non-fatal drowning may cause persistent vegetative state (VS) that is currently incurable. The aim of this paper is to present the safety and feasibility of autologous bone marrow-derived ...
and keratinocytes belongs to UCMSC-derived exosomes. Data from this study indicated that BMMSCs and UCMSCs under clinical condition secreted exosomes are promising to develop into therapeutic products for wound healing treatment.
(2020-06-24)
Exosomes are nano-scale and closed membrane vesicles which are promising for therapeutic applications due to exosome-enclosed therapeutic molecules such as DNA, small RNAs, proteins, and lipids. Recently, it has been ...
Outcomes of autologous bone marrow mononuclear cell administration in the treatment of neurologic sequelae in children with spina bifida
(2023)
Background To evaluate the safety and efcacy of autologous bone marrow mononuclear cell (BMMNC) infusion in the management of neurological sequelae in children with spina bifda (SB). Methods BMMNCs were harvested from ...
The density of bone marrow mononuclear cells and CD34+ cells in patients with three neurologic conditions
(2023)
Background This study aimed to identify the density of mononuclear cells (MNCs) and CD34+ cells in the bone mar‑row of patients with three neurologic conditions. Methods The study included 88 patients with three neurologic ...
The correlation between peripheral blood index and immune cell expansion in Vietnamese elderly lung cancer patients
(2023-02-21)
(1) Background: The dysfunction and reduced proliferation of peripheral CD8+ T cells and natural killer (NK) cells have been observed in both aging and cancer patients, thereby challenging the adoption of immune cell therapy ...