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Differential Cytotoxicity of Curcumin-Loaded Micelles on Human Tumor and Stromal Cells
(2022-10-15)
Although curcumin in the form of nanoparticles has been demonstrated as a potential anti-tumor compound, the impact of curcumin and nanocurcumin in vitro on normal cells and in vivo in animal models is largely unknown. ...
Effects of Extracellular Vesicles Secreted by TGFβ-Stimulated Umbilical Cord Mesenchymal Stem Cells on Skin Fibroblasts by Promoting Fibroblast Migration and ECM Protein Production
(2022-07-27)
Umbilical cord-derived mesenchymal stem cells (UCMSCs) have been illustrated for their roles in immunological modulation and tissue regeneration through the secretome. Additionally, culture conditions can trigger the ...
Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila
(2020-04-27)
The Immune Deficiency (IMD) pathway in Drosophila melanogaster is activated in response to microbial challenges, particularly by Gram-negative bacteria, to initiate the innate immune response. To elucidate the nuclear ...
Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management
(202-10-26)
Osteoarthritis (OA) is a prevalent degenerative disease characterized by persistent pain and restricted motion. In recent years, mesenchymal stem cells (MSCs) have emerged as a promising alternative therapy for OA due to ...